Warning: mysql_query() [function.mysql-query]: Unable to save result set in D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php on line 50
Database error: Invalid SQL: select count(id) from pwn_comment where pid='406449' and iffb='1'
MySQL Error: 1194 (Table 'pwn_comment' is marked as crashed and should be repaired)
#0 dbbase_sql->halt(Invalid SQL: select count(id) from pwn_comment where pid='406449' and iffb='1') called at [D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php:54] #1 dbbase_sql->query(select count(id) from {P}_comment where pid='406449' and iffb='1') called at [D:\wwwroot\hs21cn2043\wwwroot\comment\module\CommentContent.php:65] #2 CommentContent() called at [D:\wwwroot\hs21cn2043\wwwroot\includes\common.inc.php:551] #3 printpage() called at [D:\wwwroot\hs21cn2043\wwwroot\comment\html\index.php:13]
Warning: mysql_fetch_array(): supplied argument is not a valid MySQL result resource in D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php on line 61

Warning: mysql_query() [function.mysql-query]: Unable to save result set in D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php on line 50
Database error: Invalid SQL: select * from pwn_comment where pid='406449' and iffb='1' order by id limit 0,10
MySQL Error: 1194 (Table 'pwn_comment' is marked as crashed and should be repaired)
#0 dbbase_sql->halt(Invalid SQL: select * from pwn_comment where pid='406449' and iffb='1' order by id limit 0,10) called at [D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php:54] #1 dbbase_sql->query(select * from {P}_comment where pid='406449' and iffb='1' order by id limit 0,10) called at [D:\wwwroot\hs21cn2043\wwwroot\comment\module\CommentContent.php:167] #2 CommentContent() called at [D:\wwwroot\hs21cn2043\wwwroot\includes\common.inc.php:551] #3 printpage() called at [D:\wwwroot\hs21cn2043\wwwroot\comment\html\index.php:13]
Warning: mysql_fetch_array(): supplied argument is not a valid MySQL result resource in D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php on line 61
网友点评-Ther the brain UA transporters are in fact involved in the UA-线缆测高仪,超声波测高仪, 手持式测高仪-上海交通大学科技园上海野豹企业发展公司
网站标志
商品搜索
购物车
购物车 0 件商品 | 查看购物车 | 我的订单 | 我的积分 | 会员中心
会员登录信息
您好,欢迎光临本站!    请 登录  或  注册
点评详情
发布于:2018-6-20 08:55:16  访问:39 次 回复: 篇
版主管理 | 推荐 | 删除 | 删除并扣分
Ther the brain UA transporters are in fact involved in the UA
It has not too long ago been ITMN-191 reported that genetic variants of SLC2A9 (GLUT9) and ABCG2, which influence the serum level of UA, can modify susceptibility to PD [3, five, 6]. Additional, an elevated/reduced UA level in serum correlates closely with an elevated/reduced UA level inside the brain [34]. Additional, an elevated/reduced UA level in serum correlates closely with an elevated/reduced UA level in the brain [34]. In addition, the dysfunction of regional UA transport inside the brain might have more effects around the level of UA within the brain. GLUT9 dysfunction within the ependymal cells may well reduce the UA provide for brain parenchyma. ABCG2 dysfunction within the brain capillary endothelial cells may well inhibit UA excretion into blood and maintain the brain parenchyma UA level. Considering that various UA transporters exist around the luminal side of endothelial cells, additional investigation is required to reveal the primary driver of UA transport.extensively discussed nonetheless, the dynamics of UA transport within the brain has remained unexplored. Further clarification of the regulatory mechanism of the amount of UA inside the central nervous technique would be useful for the realization of targeted neuroprotective therapy.Abbreviations CSF: cerebrospinal fluid; KO: knockout; PD: Parkinson‘s disease; PFA: paraformaldehyde; UA: uric acid; WT: wild-type. Authors‘ contributions NHT and MH conceived, designed the study and wrote the paper. NHT performed the immunohistochemical and in situ hybridization research. TT and HS participated in the study with ABCG2 KO mouse. YT, SS and SU participated inside the style from the immunohistochemical study. All authors read and authorized the final manuscript. Author particulars 1 Department of Human Physiology and Pathology, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. two Division of Internal Medicine, Teikyo University School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. 3 Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Acknowledgements The authors thank Yui Ishiyama, Chiemi Shigetomi, Natsumi Hasebe and Seiha Katabami for technical help. Competing interests The authors declare that they have no competing interests. Availability of information PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28326783 and material All information are integrated in the manuscript. Ethics approval and consent to participate All animal experiments had been carried out in accordance with the guidelines for animal experimentation in Teikyo University along with the University of Tokyo and the project was approved by the nearby committee. Funding This perform was in element supported by Grant-in-Aid for Research Activity Start-up from Japan Society in the Promotion of Science (JSPS) (Grant No. 26893275) plus the Gout Analysis Foundation of Japan. Received: 12 October 2016 Accepted: 26 NovemberConclusions Within this study, we propose that UA inside the brain might be transported by UA transporters, which show certain expression patterns in ependymal, choroid plexus epithelial and brain capillary endothelial cells. As a result far, the value of UA in PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23108553 the brain as an antioxidant has beenReferences 1. Kutzing MK, Firestein BL. Altered uric acid levels and illness states. J Pharmacol Exp Ther. 2008;324:1?. 2.
共篇回复 每页10篇 页次:1/1
共篇回复 每页10篇 页次:1/1
我要回复
回复内容
验 证 码
看不清?更换一张
匿名发表 
当前位置
脚注信息

点击这里给我发送消息  李先生   点击这里给我发送消息  谭经理     点击这里给我发送消息   李经理   点击这里给我发送消息  友链交换  点击这里给我发消息shshujia  点击这里给我发消息shshujia1  点击这里给我发消息h6181   点击这里给我发消息yebaonet
Copyright   2013-2030 上海野豹企业发展有限公司-官方网站管理系统 版权所有   沪ICP备13003797号  服务时间:周一至周日 08:30 — 20:00 
全国订购免费电话:4006-021-638  服务热线:021-51699943   联系地址:上海市中山北路814弄21号协和大厦14楼A座   邮政编码:210070 
传 真:021-54011883   联系人:李军(经理)    手 机:18917195436   网址:www.shyebao.net  电邮:yebaonet@163.com