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MySQL Error: 1194 (Table 'pwn_comment' is marked as crashed and should be repaired)
#0 dbbase_sql->halt(Invalid SQL: select count(id) from pwn_comment where pid='399242' and iffb='1') called at [D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php:54] #1 dbbase_sql->query(select count(id) from {P}_comment where pid='399242' and iffb='1') called at [D:\wwwroot\hs21cn2043\wwwroot\comment\module\CommentContent.php:65] #2 CommentContent() called at [D:\wwwroot\hs21cn2043\wwwroot\includes\common.inc.php:551] #3 printpage() called at [D:\wwwroot\hs21cn2043\wwwroot\comment\html\index.php:13]
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Warning: mysql_query() [function.mysql-query]: Unable to save result set in D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php on line 50
Database error: Invalid SQL: select * from pwn_comment where pid='399242' and iffb='1' order by id limit 0,10
MySQL Error: 1194 (Table 'pwn_comment' is marked as crashed and should be repaired)
#0 dbbase_sql->halt(Invalid SQL: select * from pwn_comment where pid='399242' and iffb='1' order by id limit 0,10) called at [D:\wwwroot\hs21cn2043\wwwroot\includes\db.inc.php:54] #1 dbbase_sql->query(select * from {P}_comment where pid='399242' and iffb='1' order by id limit 0,10) called at [D:\wwwroot\hs21cn2043\wwwroot\comment\module\CommentContent.php:167] #2 CommentContent() called at [D:\wwwroot\hs21cn2043\wwwroot\includes\common.inc.php:551] #3 printpage() called at [D:\wwwroot\hs21cn2043\wwwroot\comment\html\index.php:13]
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网友点评-Overall survival by 8.five months within a double blind placebo controlled phase-线缆测高仪,超声波测高仪, 手持式测高仪-上海交通大学科技园上海野豹企业发展公司
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发布于:2018-6-14 07:36:58  访问:46 次 回复: 篇
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Overall survival by 8.five months within a double blind placebo controlled phase
They support optimal expression from the encoded antigen too as innate immune stimulation using a built-in adjuvanticity which is at the very least partly mediated by means of Toll-like receptor 7 activation [11, 12]. In mice, immunization with these selfadjuvanted vaccines PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28461585 leads to a boostable and balanced humoral at the same time as T cell-mediated antigen-specific immunity, that is lengthy lived as shown by presence of antigenspecific memory T cells [13, 14]. CV9103 is such a self-adjuvanted mRNA vaccine targeting 4 antigens: prostate-specific antigen (PSA), prostatespecific membrane antigen (PSMA), Isovaleryl-Val-Val-Sta-Ala-Sta-OH chemical information prostate stem cell antigen PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28878015 (PSCA), and six-transmembrane epithelial antigen in the prostate 1 (STEAP1). In wholesome men, these antigens are frequently and virtually exclusively expressed inside the prostate [15?8], and overexpressed in prostate cancer; using the exception of PSMA which is also overexpressed within the Isovaleryl-Val-Val-Sta-Ala-Sta-OH site tumor-neovasculature of other cancers [15, 19]. Right after radical prostatectomy or radiation, these antigens are primarily found on residual prostate cancer cells [20?5]. Moreover, all four antigens have been shown to become immunogenic in humans, where they induce T and B cell responses [26?8]. CV9103 encodes full-length antigens and therefore has the benefit to induce an immune response against all epitopes contained within the target protein with out HLArestrictions. This, as well as the inclusion of many antigens, was developed to minimize the risk of tumor immune escape because of loss of expression of person antigens [28], to raise the clinical efficacy by inducing a broader immune response and to provide immune responses against antigens present within the individual tumor inside a higher quantity of sufferers.Here we report the results of a phase I/IIa study that evaluated the safety and tolerability of CV9103 following intradermal administration in individuals with sophisticated CRPC. The induction of antigen-specific immune responses is also reported.ResultsPatient characteristicsBetween January and November 2009, 50 sufferers with sophisticated CRPC were screened at 12 centers in Germany and Italy. 44 sufferers were eligible, started therapy with CV9103 and have been incorporated in the security population. Of these, 12 sufferers were enrolled inside the phase I aspect from the study and 32 individuals in the phase II portion. Of all sufferers, 40 (91 ) have been evaluable for PSA response and two (five ) for tumor response in accordance with Response Evaluation Criteria in Solid Tumors (RECIST).All round survival by eight.5 months inside a double blind placebo controlled phase II trial [5]. Vaccination with messenger RNA (mRNA) encoding full-length tumor antigens is a novel alternative for immunotherapy. Early experiments showed that intradermal administration of mRNA led to protein expression and induction of humoral and cellular antigen-specific immune responses in mice [6?]. Within a phase I/II trial in sufferers with metastatic melanoma, direct intra-dermal injection of mRNA coding for relevant tumor-associated antigens was nicely tolerated and influenced the frequency of vaccineantigen directed CD4 and CD8 T cells as well as regulatory T cells (T Regs). 1 stage IV patient showed a total response of lung metastases, and following a relapse that was surgically treated remains tumor totally free until now [10].
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